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TitleAgonistic beta-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 14678-14688, Year 2018
Publish dateJul 18, 2017 (structure data deposition date)
AuthorsMin, X. / Weiszmann, J. / Johnstone, S. / Wang, W. / Yu, X. / Romanow, W. / Thibault, S. / Li, Y. / Wang, Z.
External linksJ. Biol. Chem. / PubMed:30068552
MethodsX-ray diffraction
Resolution2.7 Å
Structure data

PDB-5wi9:
Crystal structure of KL with an agonist Fab
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / beta-klotho / scaffold protein / fibroblast growth factors

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