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TitleHuman beta-defensin 2 killsCandida albicansthrough phosphatidylinositol 4,5-bisphosphate-mediated membrane permeabilization.
Journal, issue, pagesSci Adv, Vol. 4, Page eaat0979-eaat0979, Year 2018
Publish dateMar 20, 2018 (structure data deposition date)
AuthorsJarva, M. / Phan, T.K. / Lay, F.T. / Caria, S. / Kvansakul, M. / Hulett, M.D.
External linksSci Adv / PubMed:30050988
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-6cs9:
Crystal structure of human beta-defensin 2 in complex with PIP2
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-PIO:
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTIMICROBIAL PROTEIN / antimicrobial / antifungal / defensin / innate defense

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