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TitleReceptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.
Journal, issue, pagesElife, Vol. 7, Year 2018
Publish dateJul 11, 2018 (structure data deposition date)
AuthorsFerrao, R.D. / Wallweber, H. / Lupardus, P.J.
External linksElife / PubMed:30044226
MethodsX-ray diffraction
Resolution2.65 - 2.83 Å
Structure data

PDB-6e2p:
Structure of human JAK2 FERM/SH2 in complex with Leptin Receptor
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

PDB-6e2q:
Structure of human JAK2 FERM/SH2 in complex with Erythropoietin Receptor
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Cytokine Receptor / Leptin / Signal Transduction / Erythropoietin

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