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TitleStress-testing the relationship between T cell receptor/peptide-MHC affinity and cross-reactivity using peptide velcro.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page E7369-E7378, Year 2018
Publish dateOct 27, 2017 (structure data deposition date)
AuthorsGee, M.H. / Sibener, L.V. / Birnbaum, M.E. / Jude, K.M. / Yang, X. / Fernandes, R.A. / Mendoza, J.L. / Glassman, C.R. / Garcia, K.C.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:30021852
MethodsX-ray diffraction
Resolution2.307 Å
Structure data

PDB-6bga:
2B4 I-Ek TCR-MHC complex with affinity-enhancing Velcro peptide
Method: X-RAY DIFFRACTION / Resolution: 2.307 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / Complex / engineered peptide

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