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TitleFacile target validation in an animal model with intracellularly expressed monobodies.
Journal, issue, pagesNat. Chem. Biol., Vol. 14, Page 895-900, Year 2018
Publish dateDec 21, 2017 (structure data deposition date)
AuthorsGupta, A. / Xu, J. / Lee, S. / Tsai, S.T. / Zhou, B. / Kurosawa, K. / Werner, M.S. / Koide, A. / Ruthenburg, A.J. / Dou, Y. / Koide, S.
External linksNat. Chem. Biol. / PubMed:30013062
MethodsX-ray diffraction
Resolution2.69 Å
Structure data

PDB-6byn:
Crystal structure of WDR5-Mb(S4) monobody complex
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Beta-propeller / fibronectin / MLL1 / inhibitor

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