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TitleStructure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Journal, issue, pagesCell, Vol. 174, Page 300-311.e11, Year 2018
Publish dateMar 22, 2018 (structure data deposition date)
AuthorsZhou, W. / Whiteley, A.T. / de Oliveira Mann, C.C. / Morehouse, B.R. / Nowak, R.P. / Fischer, E.S. / Gray, N.S. / Mekalanos, J.J. / Kranzusch, P.J.
External linksCell / PubMed:30007416
MethodsX-ray diffraction
Resolution2.26 - 2.779 Å
Structure data

PDB-6ct9:
Structure of the human cGAS-DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-6cta:
Structure of the human cGAS-DNA complex with ATP
Method: X-RAY DIFFRACTION / Resolution: 2.779 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / cGAS / STING / Innate Immunity / transferase / TRANSFERASE-DNA complex

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