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-Structure paper
Title | Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ER alphaWTand ER alphaMUTBreast Cancer. |
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Journal, issue, pages | Cancer Discov, Vol. 8, Page 1176-1193, Year 2018 |
Publish date | Feb 23, 2018 (structure data deposition date) |
![]() | Puyang, X. / Furman, C. / Zheng, G.Z. / Wu, Z.J. / Banka, D. / Aithal, K. / Agoulnik, S. / Bolduc, D.M. / Buonamici, S. / Caleb, B. ...Puyang, X. / Furman, C. / Zheng, G.Z. / Wu, Z.J. / Banka, D. / Aithal, K. / Agoulnik, S. / Bolduc, D.M. / Buonamici, S. / Caleb, B. / Das, S. / Eckley, S. / Fekkes, P. / Hao, M.H. / Hart, A. / Houtman, R. / Irwin, S. / Joshi, J.J. / Karr, C. / Kim, A. / Kumar, N. / Kumar, P. / Kuznetsov, G. / Lai, W.G. / Larsen, N. / Mackenzie, C. / Martin, L.A. / Melchers, D. / Moriarty, A. / Nguyen, T.V. / Norris, J. / O'Shea, M. / Pancholi, S. / Prajapati, S. / Rajagopalan, S. / Reynolds, D.J. / Rimkunas, V. / Rioux, N. / Ribas, R. / Siu, A. / Sivakumar, S. / Subramanian, V. / Thomas, M. / Vaillancourt, F.H. / Wang, J. / Wardell, S. / Wick, M.J. / Yao, S. / Yu, L. / Warmuth, M. / Smith, P.G. / Zhu, P. / Korpal, M. |
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Methods | X-ray diffraction |
Resolution | 1.68 - 1.89 Å |
Structure data | ![]() PDB-6chw: ![]() PDB-6chz: |
Chemicals | ![]() ChemComp-F3D: ![]() ChemComp-EDO: ![]() ChemComp-DMS: ![]() ChemComp-HOH: |
Source |
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![]() | nuclear protein/antagonist / Nuclear hormone receptor / covalent antagonist / activating mutation / breast cancer / NUCLEAR PROTEIN / nuclear protein-antagonist complex / antagonist |