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TitleAncient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 8155-8160, Year 2018
Publish dateMay 4, 2018 (structure data deposition date)
AuthorsBanerjee, S. / Ji, C. / Mayfield, J.E. / Goel, A. / Xiao, J. / Dixon, J.E. / Guo, X.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29987021
MethodsX-ray diffraction
Resolution2.496 Å
Structure data

PDB-5ztn:
The crystal structure of human DYRK2 in complex with Curcumin
Method: X-RAY DIFFRACTION / Resolution: 2.496 Å

Chemicals

ChemComp-CUR:
(1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / inhibitor of kinase / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex

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