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TitleThe human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen.
Journal, issue, pagesSci Transl Med, Vol. 10, Year 2018
Publish dateApr 13, 2018 (structure data deposition date)
AuthorsHavenar-Daughton, C. / Sarkar, A. / Kulp, D.W. / Toy, L. / Hu, X. / Deresa, I. / Kalyuzhniy, O. / Kaushik, K. / Upadhyay, A.A. / Menis, S. ...Havenar-Daughton, C. / Sarkar, A. / Kulp, D.W. / Toy, L. / Hu, X. / Deresa, I. / Kalyuzhniy, O. / Kaushik, K. / Upadhyay, A.A. / Menis, S. / Landais, E. / Cao, L. / Diedrich, J.K. / Kumar, S. / Schiffner, T. / Reiss, S.M. / Seumois, G. / Yates, J.R. / Paulson, J.C. / Bosinger, S.E. / Wilson, I.A. / Schief, W.R. / Crotty, S.
External linksSci Transl Med / PubMed:29973404
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6d2p:
Crystal structure of IOMA-class CLK31 Fab from an HIV-1 naive donor in complex with a germline-targeting gp120 engineered outer domain eOD-GT8 at 2.6 A
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HIV-1 gp120 / engineered outer domain (eOD) / germline targeting / CD4 binding site / IOMA-class naive human germline antibody / viral-protein complex / healthy HIV-1 negative donor

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