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-Structure paper
Title | The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities. |
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Journal, issue, pages | MAbs, Vol. 10, Page 1018-1029, Year 2018 |
Publish date | Oct 26, 2017 (structure data deposition date) |
Authors | Dhagat, U. / Hercus, T.R. / Broughton, S.E. / Nero, T.L. / Cheung Tung Shing, K.S. / Barry, E.F. / Thomson, C.A. / Bryson, S. / Pai, E.F. / McClure, B.J. ...Dhagat, U. / Hercus, T.R. / Broughton, S.E. / Nero, T.L. / Cheung Tung Shing, K.S. / Barry, E.F. / Thomson, C.A. / Bryson, S. / Pai, E.F. / McClure, B.J. / Schrader, J.W. / Lopez, A.F. / Parker, M.W. |
External links | MAbs / PubMed:29969365 |
Methods | X-ray diffraction |
Resolution | 2 - 2.6 Å |
Structure data | PDB-6bfq: PDB-6bfs: |
Chemicals | ChemComp-HOH: |
Source |
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Keywords | IMMUNE SYSTEM / cytokine-Fab complex / Pulmonary Alveolar Proteinosis / receptor assembly / autoantibodies |