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TitleRefinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 Å Resolution.
Journal, issue, pagesStructure, Vol. 26, Issue 9, Page 1169-11177.e3, Year 2018
Publish dateSep 4, 2018
AuthorsMadhumati Sevvana / Feng Long / Andrew S Miller / Thomas Klose / Geeta Buda / Lei Sun / Richard J Kuhn / Michael G Rossmann /
PubMed AbstractAmong the several arthropod-borne human flaviviral diseases, the recent outbreak of Zika virus (ZIKV) has caused devastating birth defects and neurological disorders, challenging the world with ...Among the several arthropod-borne human flaviviral diseases, the recent outbreak of Zika virus (ZIKV) has caused devastating birth defects and neurological disorders, challenging the world with another major public health concern. We report here the refined structure of the mature ZIKV at a resolution of 3.1 Å as determined by cryo-electron microscopic single-particle reconstruction. The improvement in the resolution, compared with previous enveloped virus structures, was the result of optimized virus preparation methods and data processing techniques. The glycoprotein interactions and surface properties of ZIKV were compared with other mosquito-borne flavivirus structures. The largest structural differences and sequence variations occur at the glycosylation loop associated with receptor binding. Probable drug binding pockets were identified on the viral surface. These results also provide a structural basis for the design of vaccines against ZIKV.
External linksStructure / PubMed:29958768 / PubMed Central
MethodsEM (single particle)
Resolution3.1 Å
Structure data

7543

6co8

EMDB-7543, PDB-6co8:
Structure of Zika virus at a resolution of 3.1 Angstrom
Method: EM (single particle) / Resolution: 3.1 Å

Source
  • isolate ZIKV/Human/French Polynesia/10087PF/2013 (virus)
  • zika virus zikv/h. sapiens/frenchpolynesia/10087pf/2013
KeywordsVIRUS / Zika / flavivirus

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