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Title | X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. |
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Journal, issue, pages | Eur J Med Chem, Vol. 155, Page 806-823, Year 2018 |
Publish date | Nov 7, 2017 (structure data deposition date) |
Authors | Yang, L.L. / Wang, H.L. / Zhong, L. / Yuan, C. / Liu, S.Y. / Yu, Z.J. / Liu, S. / Yan, Y.H. / Wu, C. / Wang, Y. ...Yang, L.L. / Wang, H.L. / Zhong, L. / Yuan, C. / Liu, S.Y. / Yu, Z.J. / Liu, S. / Yan, Y.H. / Wu, C. / Wang, Y. / Wang, Z. / Yu, Y. / Chen, Q. / Li, G.B. |
External links | Eur J Med Chem / PubMed:29957526 |
Methods | X-ray diffraction |
Resolution | 1.483 - 1.735 Å |
Structure data | PDB-5yql: PDB-5yqm: PDB-5yqn: PDB-5yqo: |
Chemicals | ChemComp-A2I: ChemComp-ZN: ChemComp-BME: ChemComp-HOH: ChemComp-A2X: ChemComp-L55: ChemComp-PEG: ChemComp-L5C: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / NAD-dependent deacetylase sirtuin-2 / Inhibitor / Complex / HYDROLASE-HYDROLASE INHIBITOR complex |