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TitleA potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 12663-12680, Year 2018
Publish dateMay 9, 2017 (structure data deposition date)
AuthorsSananes, A. / Cohen, I. / Shahar, A. / Hockla, A. / De Vita, E. / Miller, A.K. / Radisky, E.S. / Papo, N.
External linksJ. Biol. Chem. / PubMed:29934309
MethodsX-ray diffraction
Resolution1.853 - 2.296 Å
Structure data

PDB-5nx1:
Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy
Method: X-RAY DIFFRACTION / Resolution: 1.853 Å

PDB-5nx3:
Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy
Method: X-RAY DIFFRACTION / Resolution: 2.296 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Serine_protease / inhibitor / complex / Hydrolase-Inhibitor complex

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