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TitleConformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.
Journal, issue, pagesNat Commun, Vol. 9, Page 2422-2422, Year 2018
Publish dateDec 15, 2017 (structure data deposition date)
AuthorsPetrie, E.J. / Sandow, J.J. / Jacobsen, A.V. / Smith, B.J. / Griffin, M.D.W. / Lucet, I.S. / Dai, W. / Young, S.N. / Tanzer, M.C. / Wardak, A. ...Petrie, E.J. / Sandow, J.J. / Jacobsen, A.V. / Smith, B.J. / Griffin, M.D.W. / Lucet, I.S. / Dai, W. / Young, S.N. / Tanzer, M.C. / Wardak, A. / Liang, L.Y. / Cowan, A.D. / Hildebrand, J.M. / Kersten, W.J.A. / Lessene, G. / Silke, J. / Czabotar, P.E. / Webb, A.I. / Murphy, J.M.
External linksNat Commun / PubMed:29930286
MethodsX-ray diffraction
Resolution2.79 Å
Structure data

PDB-6bwk:
Crystal structure of the human MLKL pseudokinase domain T357E/S358E mutant
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Pseudokinase / Necroptosis

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