タイトル | Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells. |
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ジャーナル・号・ページ | Oncotarget, Vol. 9, Page 26800-26816, Year 2018 |
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掲載日 | 2017年12月28日 (構造データの登録日) |
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著者 | Kazokaite, J. / Niemans, R. / Dudutiene, V. / Becker, H.M. / Leitans, J. / Zubriene, A. / Baranauskiene, L. / Gondi, G. / Zeidler, R. / Matuliene, J. ...Kazokaite, J. / Niemans, R. / Dudutiene, V. / Becker, H.M. / Leitans, J. / Zubriene, A. / Baranauskiene, L. / Gondi, G. / Zeidler, R. / Matuliene, J. / Tars, K. / Yaromina, A. / Lambin, P. / Dubois, L.J. / Matulis, D. |
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リンク | Oncotarget / PubMed:29928486 |
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手法 | X線回折 |
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解像度 | 1.75 - 2.47 Å |
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構造データ | PDB-6fe0: Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide. 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-6fe1: Three dimensional structure of human carbonic anhydrase IX in complex with benzenesulfonamide. 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6fe2: Three dimensional structure of human carbonic anhydrase IX 手法: X-RAY DIFFRACTION / 解像度: 1.87 Å PDB-6g98: Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 2.47 Å PDB-6g9u: Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å |
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化合物 | ChemComp-V14: 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide
ChemComp-ER5: 4-[2-[3-(cyclododecylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic acid
ChemComp-ETK: 4-[2-[3-(cyclooctylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic acid
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由来 | homo sapiens (ヒト)
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キーワード | LYASE |
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