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TitleNADP+-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione.
Journal, issue, pagesJ. Biol. Inorg. Chem., Vol. 23, Page 849-860, Year 2018
Publish dateDec 14, 2017 (structure data deposition date)
AuthorsCho, H.J. / Cho, H.Y. / Park, J.W. / Kwon, O.S. / Lee, H.S. / Huh, T.L. / Kang, B.S.
External linksJ. Biol. Inorg. Chem. / PubMed:29923039
MethodsX-ray diffraction
Resolution1.994 - 2.519 Å
Structure data

PDB-5yzh:
Crystal Structure of Mouse Cytosolic Isocitrate Dehydrogenase
Method: X-RAY DIFFRACTION / Resolution: 1.994 Å

PDB-5yzi:
Crystal Structure of Mouse Cytosolic Isocitrate Dehydrogenase complexed with Cadmium
Method: X-RAY DIFFRACTION / Resolution: 2.519 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-CD:
Unknown entry

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE / IDH

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