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TitleMechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 6792-6797, Year 2018
Publish dateDec 22, 2017 (structure data deposition date)
AuthorsYang, J. / Liu, Z. / Wang, C. / Yang, R. / Rathkey, J.K. / Pinkard, O.W. / Shi, W. / Chen, Y. / Dubyak, G.R. / Abbott, D.W. / Xiao, T.S.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29891674
MethodsX-ray diffraction
Resolution1.796 Å
Structure data

PDB-6bz9:
Crystal structure of human caspase-1 in complex with Ac-FLTD-CMK
Method: X-RAY DIFFRACTION / Resolution: 1.796 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/HYDROLASE INHIBITOR / inhibitor / complex / HYDROLASE-HYDROLASE INHIBITOR complex

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