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Structure paper

TitleModular ssDNA binding and inhibition of telomerase activity by designer PPR proteins.
Journal, issue, pagesNat Commun, Vol. 9, Page 2212-2212, Year 2018
Publish dateAug 16, 2017 (structure data deposition date)
AuthorsSpahr, H. / Chia, T. / Lingford, J.P. / Siira, S.J. / Cohen, S.B. / Filipovska, A. / Rackham, O.
External linksNat Commun / PubMed:29880855
MethodsX-ray diffraction
Resolution1.95 - 2.08 Å
Structure data

PDB-5orm:
Crystal structure of designed cPPR-Telo1
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

PDB-5orq:
Crystal structure of designed cPPR-Telo1 in complex with ssDNA
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsDE NOVO PROTEIN / designer nucleic acid-binding proteins / pentatricopeptide repeat / telomerase

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