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Structure paper

TitleStructure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 10895-10910, Year 2018
Publish dateFeb 27, 2018 (structure data deposition date)
AuthorsRege, N.K. / Wickramasinghe, N.P. / Tustan, A.N. / Phillips, N.F.B. / Yee, V.C. / Ismail-Beigi, F. / Weiss, M.A.
External linksJ. Biol. Chem. / PubMed:29880646
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-6ck2:
Insulin analog containing a YB26W mutation
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-IPH:
PHENOL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHORMONE / Long-acting / Basal / Therapeutic / Peptide Hormone / Diabetes / Biomolecular Engineering

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