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TitleStructures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.
Journal, issue, pagesJ. Mol. Biol., Vol. 430, Page 2857-2872, Year 2018
Publish dateAug 25, 2017 (structure data deposition date)
AuthorsVanarotti, M. / Grace, C.R. / Miller, D.J. / Actis, M.L. / Inoue, A. / Evison, B.J. / Vaithiyalingam, S. / Singh, A.P. / McDonald, E.T. / Fujii, N.
External linksJ. Mol. Biol. / PubMed:29864443
MethodsX-ray diffraction / NMR (solution)
Resolution2.356 Å
Structure data

PDB-6asr:
REV1 UBM2 domain complex with ubiquitin
Method: X-RAY DIFFRACTION / Resolution: 2.356 Å

PDB-6axd:
Structures of REV1 UBM2 domain complex with ubiquitin and with the first small-molecule that inhibits the REV1 UBM2-ubiquitin interaction
Method: SOLUTION NMR

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / ubiquitin-binding motif / protein-protein interaction / TRANSFERASE/TRANSFERASE INHIBITOR / STRUCTURAL PROTEIN / TRANSFERASE-TRANSFERASE INHIBITOR complex

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