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Structure paper

TitleDisease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.
Journal, issue, pagesCell Rep, Vol. 23, Page 2805-2818, Year 2018
Publish dateNov 4, 2017 (structure data deposition date)
AuthorsJoseph, N. / Al-Jassar, C. / Johnson, C.M. / Andreeva, A. / Barnabas, D.D. / Freund, S.M.V. / Gergely, F. / van Breugel, M.
External linksCell Rep / PubMed:29847808
MethodsX-ray diffraction
Resolution1.4 - 2.1 Å
Structure data

PDB-6ewg:
Oreochromis niloticus CEP120 second C2 domain (C2B)
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6ewh:
Oreochromis niloticus CEP120 second C2 domain (C2B) G307S mutant
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-6ewi:
Oreochromis niloticus CEP120 second C2 domain (C2B) A200P + G307S mutant
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-6ewl:
Danio rerio CEP120 first C2 domain (C2A)
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-6ewp:
Mus musculus CEP120 third C2 domain (C2C)
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-P6G:
HEXAETHYLENE GLYCOL / precipitant*YM

Source
  • oreochromis niloticus (Nile tilapia)
  • danio rerio (zebrafish)
  • mus musculus (house mouse)
KeywordsCYTOSOLIC PROTEIN / Centriole Centrosome Basal body Cilia / Centriole / Centrosome / Basal body / Cilia

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