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-Structure paper
タイトル | Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 61, Page 5245-5256, Year 2018 |
掲載日 | 2018年1月5日 (構造データの登録日) |
![]() | Come, J.H. / Collier, P.N. / Henderson, J.A. / Pierce, A.C. / Davies, R.J. / Le Tiran, A. / O'Dowd, H. / Bandarage, U.K. / Cao, J. / Deininger, D. ...Come, J.H. / Collier, P.N. / Henderson, J.A. / Pierce, A.C. / Davies, R.J. / Le Tiran, A. / O'Dowd, H. / Bandarage, U.K. / Cao, J. / Deininger, D. / Grey, R. / Krueger, E.B. / Lowe, D.B. / Liang, J. / Liao, Y. / Messersmith, D. / Nanthakumar, S. / Sizensky, E. / Wang, J. / Xu, J. / Chin, E.Y. / Damagnez, V. / Doran, J.D. / Dworakowski, W. / Griffith, J.P. / Jacobs, M.D. / Khare-Pandit, S. / Mahajan, S. / Moody, C.S. / Aronov, A.M. |
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手法 | X線回折 |
解像度 | 2.31 Å |
構造データ | ![]() PDB-6c1s: |
化合物 | ![]() ChemComp-EFV: ![]() ChemComp-SO4: ![]() ChemComp-HOH: |
由来 |
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![]() | Transferase/Transferase Inhibitor / kinase / inhibitor / Transferase-Transferase Inhibitor complex |