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Structure paper

TitleStructural basis for signal recognition and transduction by platelet-activating-factor receptor.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 25, Page 488-495, Year 2018
Publish dateMar 25, 2018 (structure data deposition date)
AuthorsCao, C. / Tan, Q. / Xu, C. / He, L. / Yang, L. / Zhou, Y. / Qiao, A. / Lu, M. / Yi, C. / Han, G.W. ...Cao, C. / Tan, Q. / Xu, C. / He, L. / Yang, L. / Zhou, Y. / Qiao, A. / Lu, M. / Yi, C. / Han, G.W. / Wang, X. / Li, X. / Yang, H. / Rao, Z. / Jiang, H. / Zhao, Y. / Liu, J. / Stevens, R.C. / Zhao, Q. / Zhang, X.C. / Wu, B.
External linksNat. Struct. Mol. Biol. / PubMed:29808000
MethodsX-ray diffraction
Resolution2.81 - 2.9 Å
Structure data

PDB-5zkp:
Crystal structure of the human platelet-activating factor receptor in complex with SR 27417
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

PDB-5zkq:
Crystal structure of the human platelet-activating factor receptor in complex with ABT-491
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-9ER:
N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-9EU:
4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide

ChemComp-OLC:
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate

ChemComp-ZN:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • desulfovibrio vulgaris (bacteria)
  • enterobacteria phage t4 (virus)
KeywordsSIGNALING PROTEIN / G protein-coupled receptor / Platelet-activating factor receptor / Complex

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