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Structure paper

TitleCrystal structure of EGFR T790M/C797S/V948R in complex with EAI045.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 502, Page 332-337, Year 2018
Publish dateMay 15, 2018 (structure data deposition date)
AuthorsZhao, P. / Yao, M.Y. / Zhu, S.J. / Chen, J.Y. / Yun, C.H.
External linksBiochem. Biophys. Res. Commun. / PubMed:29802850
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-5zwj:
Crystal structure of EGFR 675-1022 T790M/C797S/V948R in complex with EAI045
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-9LL:
(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / EGFR T790M / C797S / EAI045 / SIGNALING PROTEIN

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