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TitleGlobal conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions.
Journal, issue, pagesBiochem. J., Vol. 475, Page 2179-2190, Year 2018
Publish dateDec 22, 2017 (structure data deposition date)
AuthorsBurvenich, I.J.G. / Farrugia, W. / Liu, Z. / Makris, D. / King, D. / Gloria, B. / Perani, A. / Allan, L.C. / Scott, A.M. / Ramsland, P.A.
External linksBiochem. J. / PubMed:29794155
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-6bz4:
Human IgG1 lacking complement-dependent cytotoxicity: hu3S193 Fc mutant K322A
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Immunoglobulin G / Fc engineering / complement dependent cytotoxicity

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