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-Structure paper
Title | Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 5279-5291, Year 2018 |
Publish date | Dec 18, 2017 (structure data deposition date) |
Authors | Drapier, T. / Geubelle, P. / Bouckaert, C. / Nielsen, L. / Laulumaa, S. / Goffin, E. / Dilly, S. / Francotte, P. / Hanson, J. / Pochet, L. ...Drapier, T. / Geubelle, P. / Bouckaert, C. / Nielsen, L. / Laulumaa, S. / Goffin, E. / Dilly, S. / Francotte, P. / Hanson, J. / Pochet, L. / Kastrup, J.S. / Pirotte, B. |
External links | J. Med. Chem. / PubMed:29775064 |
Methods | X-ray diffraction |
Resolution | 1.4 Å |
Structure data | PDB-6faz: |
Chemicals | ChemComp-SO4: ChemComp-PEG: ChemComp-GOL: ChemComp-CL: ChemComp-ACT: ChemComp-GLU: ChemComp-EDO: ChemComp-D45: ChemComp-HOH: |
Source |
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Keywords | MEMBRANE PROTEIN / AMPA receptor / GluA2 / Ligand-binding Domain / GluA2-S1S2J / positive allosteric modulator |