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TitleLectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 10646-10662, Year 2018
Publish dateOct 18, 2017 (structure data deposition date)
Authorsvan Eijk, M. / Rynkiewicz, M.J. / Khatri, K. / Leymarie, N. / Zaia, J. / White, M.R. / Hartshorn, K.L. / Cafarella, T.R. / van Die, I. / Hessing, M. ...van Eijk, M. / Rynkiewicz, M.J. / Khatri, K. / Leymarie, N. / Zaia, J. / White, M.R. / Hartshorn, K.L. / Cafarella, T.R. / van Die, I. / Hessing, M. / Seaton, B.A. / Haagsman, H.P.
External linksJ. Biol. Chem. / PubMed:29769321
MethodsX-ray diffraction
Resolution1.898 Å
Structure data

PDB-6bbd:
Structure of N-glycosylated porcine surfactant protein-D complexed with glycerol
Method: X-RAY DIFFRACTION / Resolution: 1.898 Å

PDB-6bbe:
Structure of N-glycosylated porcine surfactant protein-D
Method: X-RAY DIFFRACTION / Resolution: 1.898 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-1PG:
2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL

Source
  • sus scrofa (pig)
KeywordsSURFACTANT PROTEIN / innate immunity / surfactant / N-linked glycan / C-type lectin

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