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Title | Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 4561-4577, Year 2018 |
Publish date | Feb 8, 2018 (structure data deposition date) |
![]() | Ghosh, A.K. / R Nyalapatla, P. / Kovela, S. / Rao, K.V. / Brindisi, M. / Osswald, H.L. / Amano, M. / Aoki, M. / Agniswamy, J. / Wang, Y.F. ...Ghosh, A.K. / R Nyalapatla, P. / Kovela, S. / Rao, K.V. / Brindisi, M. / Osswald, H.L. / Amano, M. / Aoki, M. / Agniswamy, J. / Wang, Y.F. / Weber, I.T. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.13 - 1.25 Å |
Structure data | ![]() PDB-6cdj: ![]() PDB-6cdl: |
Chemicals | ![]() ChemComp-GR8: ![]() ChemComp-NA: ![]() ChemComp-CL: ![]() ChemComp-GOL: ![]() ChemComp-ACT: ![]() ChemComp-HOH: ![]() ChemComp-GR5: |
Source |
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![]() | HYDROLASE/HYDROLASE inhibitor / aspartic acid protease / HIV-1 protease inhibitor of GRL-03314A / Umb-THF / antiviral / multidrug-resistant / synthesis / backbone binding / HYDROLASE / HYDROLASE-HYDROLASE inhibitor complex |