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TitleBenzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer.
Journal, issue, pagesEur. J. Med. Chem., Vol. 152, Page 542-559, Year 2018
Publish dateNov 8, 2017 (structure data deposition date)
AuthorsXue, X. / Zhang, Y. / Wang, C. / Zhang, M. / Xiang, Q. / Wang, J. / Wang, A. / Li, C. / Zhang, C. / Zou, L. ...Xue, X. / Zhang, Y. / Wang, C. / Zhang, M. / Xiang, Q. / Wang, J. / Wang, A. / Li, C. / Zhang, C. / Zou, L. / Wang, R. / Wu, S. / Lu, Y. / Chen, H. / Ding, K. / Li, G. / Xu, Y.
External linksEur. J. Med. Chem. / PubMed:29758518
MethodsX-ray diffraction
Resolution1.82 Å
Structure data

PDB-5yqx:
Crystal Structure Analysis of the BRD4
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

Chemicals

ChemComp-E0K:
(2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / BET / BRD4 / Bromodomain

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