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Structure paper

TitleA "cross-stitched" peptide with improved helicity and proteolytic stability.
Journal, issue, pagesOrg. Biomol. Chem., Vol. 16, Page 3702-3706, Year 2018
Publish dateJul 14, 2017 (structure data deposition date)
AuthorsSpeltz, T.E. / Mayne, C.G. / Fanning, S.W. / Siddiqui, Z. / Tajkhorshid, E. / Greene, G.L. / Moore, T.W.
External linksOrg. Biomol. Chem. / PubMed:29725689
MethodsX-ray diffraction
Resolution1.8 - 2.3 Å
Structure data

PDB-5wgd:
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-5wgq:
Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-BCP1
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-EST:
ESTRADIOL / hormone*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / Breast Cancer / Stapled Peptides / Synthetic Peptides / Hormone / transcription/transcription inhibitor / Hormone. / transcription-transcription inhibitor complex

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