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TitlePharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
Journal, issue, pagesPLoS ONE, Vol. 13, Page e0196791-e0196791, Year 2018
Publish dateFeb 21, 2018 (structure data deposition date)
AuthorsMoyer, B.D. / Murray, J.K. / Ligutti, J. / Andrews, K. / Favreau, P. / Jordan, J.B. / Lee, J.H. / Liu, D. / Long, J. / Sham, K. ...Moyer, B.D. / Murray, J.K. / Ligutti, J. / Andrews, K. / Favreau, P. / Jordan, J.B. / Lee, J.H. / Liu, D. / Long, J. / Sham, K. / Shi, L. / Stocklin, R. / Wu, B. / Yin, R. / Yu, V. / Zou, A. / Biswas, K. / Miranda, L.P.
External linksPLoS ONE / PubMed:29723257
MethodsNMR (solution)
Structure data

PDB-6cgw:
Solution NMR structure of JzTx-V, a Nav 1.7 inhibitory peptide
Method: SOLUTION NMR

PDB-6chc:
JzTx-V toxin peptide, wild-type
Method: SOLUTION NMR

Source
  • chilobrachys guangxiensis (spider)
KeywordsTOXIN / Fractionated Tarantula venom / Nav 1.7 inhibitor / JzTx-V wild type peptide toxin

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