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TitleDeveloping an Anticancer Copper(II) Multitarget Pro-Drug Based on the His146 Residue in the IB Subdomain of Modified Human Serum Albumin.
Journal, issue, pagesMol. Pharm., Vol. 15, Page 2180-2193, Year 2018
Publish dateSep 2, 2017 (structure data deposition date)
AuthorsWang, J. / Gou, Y. / Zhang, Z. / Yu, P. / Qi, J. / Qin, Q. / Sun, H. / Wu, X. / Liang, H. / Yang, F.
External linksMol. Pharm. / PubMed:29722993
MethodsX-ray diffraction
Resolution2.616 Å
Structure data

PDB-5yb1:
Structure and function of human serum albumin-metal agent complex
Method: X-RAY DIFFRACTION / Resolution: 2.616 Å

Chemicals

ChemComp-PLM:
PALMITIC ACID

ChemComp-8ZR:
~{N},~{N},12-trimethyl-3$l^{3}-thia-1$l^{4},5,6$l^{4}-triaza-2$l^{3}-cupratricyclo[6.4.0.0^{2,6}]dodeca-1(8),3,6,9,11-pentaen-4-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / albumin / metal complex / pro-drug / drug carrier / target therapy

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