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Structure paper

TitleDirect binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Journal, issue, pagesNat Commun, Vol. 9, Page 1731-1731, Year 2018
Publish dateJul 18, 2017 (structure data deposition date)
AuthorsLiu, Y. / Gupta, G.D. / Barnabas, D.D. / Agircan, F.G. / Mehmood, S. / Wu, D. / Coyaud, E. / Johnson, C.M. / McLaughlin, S.H. / Andreeva, A. ...Liu, Y. / Gupta, G.D. / Barnabas, D.D. / Agircan, F.G. / Mehmood, S. / Wu, D. / Coyaud, E. / Johnson, C.M. / McLaughlin, S.H. / Andreeva, A. / Freund, S.M.V. / Robinson, C.V. / Cheung, S.W.T. / Raught, B. / Pelletier, L. / van Breugel, M.
External linksNat Commun / PubMed:29712910
MethodsX-ray diffraction
Resolution1.67 - 4.6 Å
Structure data

PDB-5oi7:
Human CEP85 - coiled coil domain 4
Method: X-RAY DIFFRACTION / Resolution: 1.67 Å

PDB-5oi9:
Trichoplax adhaerens STIL N-terminal domain
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-5oid:
Complex Trichoplax STIL-NTD:human CEP85 coiled coil domain 4
Method: X-RAY DIFFRACTION / Resolution: 4.6 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
  • trichoplax adhaerens (invertebrata)
KeywordsPROTEIN BINDING / Centrosomes / centriole / CEP85 / STIL

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