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TitleStructural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Journal, issue, pagesSci Rep, Vol. 8, Page 6412-6412, Year 2018
Publish dateMar 8, 2018 (structure data deposition date)
AuthorsArndt, J.W. / Qian, F. / Smith, B.A. / Quan, C. / Kilambi, K.P. / Bush, M.W. / Walz, T. / Pepinsky, R.B. / Bussiere, T. / Hamann, S. ...Arndt, J.W. / Qian, F. / Smith, B.A. / Quan, C. / Kilambi, K.P. / Bush, M.W. / Walz, T. / Pepinsky, R.B. / Bussiere, T. / Hamann, S. / Cameron, T.O. / Weinreb, P.H.
External linksSci Rep / PubMed:29686315
MethodsX-ray diffraction
Resolution2.09 - 2.384 Å
Structure data

PDB-6cnr:
aducanumab apo Fab
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

PDB-6co3:
aducanumab abeta complex
Method: X-RAY DIFFRACTION / Resolution: 2.384 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / antibody Fab fragment

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