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Structure paper

TitleDruggable negative allosteric site of P2X3 receptors.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 4939-4944, Year 2018
Publish dateNov 25, 2017 (structure data deposition date)
AuthorsWang, J. / Wang, Y. / Cui, W.W. / Huang, Y. / Yang, Y. / Liu, Y. / Zhao, W.S. / Cheng, X.Y. / Sun, W.S. / Cao, P. ...Wang, J. / Wang, Y. / Cui, W.W. / Huang, Y. / Yang, Y. / Liu, Y. / Zhao, W.S. / Cheng, X.Y. / Sun, W.S. / Cao, P. / Zhu, M.X. / Wang, R. / Hattori, M. / Yu, Y.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29674445
MethodsX-ray diffraction
Resolution3.4 Å
Structure data

PDB-5yve:
Crystal structure of human P2X3 receptor in complex with the AF-219 negative allosteric modulator
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-AF9:
5-[2,4-bis(azanyl)pyrimidin-5-yl]oxy-2-methoxy-4-propan-2-yl-benzenesulfonamide

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / ion channels / ATP

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