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Structure paper

TitleMechanism of NMDA receptor channel block by MK-801 and memantine.
Journal, issue, pagesNature, Vol. 556, Page 515-519, Year 2018
Publish dateJan 30, 2017 (structure data deposition date)
AuthorsSong, X. / Jensen, M.O. / Jogini, V. / Stein, R.A. / Lee, C.H. / Mchaourab, H.S. / Shaw, D.E. / Gouaux, E.
External linksNature / PubMed:29670280
MethodsX-ray diffraction
Resolution3.6 Å
Structure data

PDB-5un1:
Crystal structure of GluN1/GluN2B delta-ATD NMDA receptor
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

Chemicals

ChemComp-GLY:
GLYCINE

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-GLU:
GLUTAMIC ACID

ChemComp-BMK:
(5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene / neurotransmitter*YM

ChemComp-MG:
Unknown entry

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

Source
  • xenopus laevis (African clawed frog)
KeywordsMEMBRANE PROTEINS/INHIBITOR / Complex / Arrangement / channel blocker / MEMBRANE PROTEINS-INHIBITOR complex

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