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Structure paper

TitleIRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Journal, issue, pagesElife, Vol. 7, Year 2018
Publish dateDec 2, 2016 (structure data deposition date)
AuthorsYoneyama, Y. / Lanzerstorfer, P. / Niwa, H. / Umehara, T. / Shibano, T. / Yokoyama, S. / Chida, K. / Weghuber, J. / Hakuno, F. / Takahashi, S.I.
External linksElife / PubMed:29661273
MethodsX-ray diffraction
Resolution2.597 - 3.095 Å
Structure data

PDB-5wrk:
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y608 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.62 Å

PDB-5wrl:
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y628 peptide
Method: X-RAY DIFFRACTION / Resolution: 3.095 Å

PDB-5wrm:
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y658 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.597 Å

Chemicals

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
KeywordsENDOCYTOSIS / clathrin adaptor AP-2 complex subunit / peptide complex

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