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Structure paper

TitleStructural Basis of Splicing Modulation by Antitumor Macrolide Compounds.
Journal, issue, pagesMol. Cell, Vol. 70, Page 265-273.e8, Year 2018
Publish dateOct 4, 2017 (structure data deposition date)
AuthorsCretu, C. / Agrawal, A.A. / Cook, A. / Will, C.L. / Fekkes, P. / Smith, P.G. / Luhrmann, R. / Larsen, N. / Buonamici, S. / Pena, V.
External linksMol. Cell / PubMed:29656923
MethodsX-ray diffraction
Resolution3.08 Å
Structure data

PDB-6en4:
SF3b core in complex with a splicing modulator
Method: X-RAY DIFFRACTION / Resolution: 3.08 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-BGZ:
[(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{S})-6-methyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] ethanoate

Source
  • homo sapiens (human)
KeywordsSPLICING / Protein complex / splicing modulator

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