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TitleDefective immuno- and thymoproteasome assembly causes severe immunodeficiency.
Journal, issue, pagesSci Rep, Vol. 8, Page 5975-5975, Year 2018
Publish dateJun 9, 2015 (structure data deposition date)
AuthorsTreise, I. / Huber, E.M. / Klein-Rodewald, T. / Heinemeyer, W. / Grassmann, S.A. / Basler, M. / Adler, T. / Rathkolb, B. / Helming, L. / Andres, C. ...Treise, I. / Huber, E.M. / Klein-Rodewald, T. / Heinemeyer, W. / Grassmann, S.A. / Basler, M. / Adler, T. / Rathkolb, B. / Helming, L. / Andres, C. / Klaften, M. / Landbrecht, C. / Wieland, T. / Strom, T.M. / McCoy, K.D. / Macpherson, A.J. / Wolf, E. / Groettrup, M. / Ollert, M. / Neff, F. / Gailus-Durner, V. / Fuchs, H. / Hrabe de Angelis, M. / Groll, M. / Busch, D.H.
External linksSci Rep / PubMed:29654304
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-5bxl:
Yeast 20S proteasome beta2-G170A mutant
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-5bxn:
Yeast 20S proteasome beta2-G170A mutant in complex with Bortezomib
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-BO2:
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE / medication, anticancer*YM

Source
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
  • synthetic construct (others)
KeywordsHYDROLASE / Immunodeficiency / Proteasome / Mutant / Assembly Defect / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR complex

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