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Structure paper

TitleControlling the Oligomerization State of A beta-Derived Peptides with Light.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 140, Page 5842-5852, Year 2018
Publish dateFeb 19, 2018 (structure data deposition date)
AuthorsSalveson, P.J. / Haerianardakani, S. / Thuy-Boun, A. / Kreutzer, A.G. / Nowick, J.S.
External linksJ. Am. Chem. Soc. / PubMed:29627987
MethodsX-ray diffraction
Resolution2.03 - 2.083 Å
Structure data

PDB-6cg3:
Macrocyclic peptide derived from Abeta(17-36) - (ORN)LV(PHI)FAED(ORN)AII(2-nitrobenzylglycine)L(ORN)V
Method: X-RAY DIFFRACTION / Resolution: 2.03 Å

PDB-6cg4:
Covalently crosslinked trimer of a macrocyclic peptide derived from Abeta(17-36) - (ORN)LCVFFCED(ORN)AII(2-nitrobenzylglycine)L(ORN)V
Method: X-RAY DIFFRACTION / Resolution: 2.083 Å

PDB-6cg5:
Covalently crosslinked trimer of a macrocyclic peptide derived from Abeta (17-36) - (ORN)LCVFFCED(ORN)AII(2-nitrobenzylglycine)L(ORN)V
Method: X-RAY DIFFRACTION / Resolution: 2.08 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-IOD:
IODIDE ION

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

Source
  • synthetic construct (others)
KeywordsNEUROPEPTIDE / Amyloid / oligomer / Alzheimer's Disease / Abeta

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