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Structure paper

TitleOdilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site.
Journal, issue, pagesMol. Cell, Vol. 70, Page 83-94.e7, Year 2018
Publish dateJan 30, 2018 (structure data deposition date)
AuthorsPantel, L. / Florin, T. / Dobosz-Bartoszek, M. / Racine, E. / Sarciaux, M. / Serri, M. / Houard, J. / Campagne, J.M. / de Figueiredo, R.M. / Midrier, C. ...Pantel, L. / Florin, T. / Dobosz-Bartoszek, M. / Racine, E. / Sarciaux, M. / Serri, M. / Houard, J. / Campagne, J.M. / de Figueiredo, R.M. / Midrier, C. / Gaudriault, S. / Givaudan, A. / Lanois, A. / Forst, S. / Aumelas, A. / Cotteaux-Lautard, C. / Bolla, J.M. / Vingsbo Lundberg, C. / Huseby, D.L. / Hughes, D. / Villain-Guillot, P. / Mankin, A.S. / Polikanov, Y.S. / Gualtieri, M.
External linksMol. Cell / PubMed:29625040
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6cae:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-K:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
  • thermus thermophilus hb8 (bacteria)
  • thermus thermophilus (strain hb8 / atcc 27634 / dsm 579) (bacteria)
  • enterobacteria phage t4 (virus)
  • synthetic construct (others)
KeywordsRIBOSOME/INHIBITOR / NOSO-95179 / odilorhabdin / antibiotic / inhibitor / ribosome / 70S / ribosome structure / inhibition of translation / decoding center / RIBOSOME-INHIBITOR complex

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