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TitleSynthesis of Avibactam Derivatives and Activity on beta-Lactamases and Peptidoglycan Biosynthesis Enzymes of Mycobacteria.
Journal, issue, pagesChemistry, Vol. 24, Page 8081-8086, Year 2018
Publish dateJan 19, 2018 (structure data deposition date)
AuthorsEdoo, Z. / Iannazzo, L. / Compain, F. / Li de la Sierra Gallay, I. / van Tilbeurgh, H. / Fonvielle, M. / Bouchet, F. / Le Run, E. / Mainardi, J.L. / Arthur, M. ...Edoo, Z. / Iannazzo, L. / Compain, F. / Li de la Sierra Gallay, I. / van Tilbeurgh, H. / Fonvielle, M. / Bouchet, F. / Le Run, E. / Mainardi, J.L. / Arthur, M. / Etheve-Quelquejeu, M. / Hugonnet, J.E.
External linksChemistry / PubMed:29601108
MethodsX-ray diffraction
Resolution2.69 Å
Structure data

PDB-6fj1:
Structure of the Ldtfm-avibactam carbamoyl enzyme
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-P3G:
3,6,9,12,15-PENTAOXAHEPTADECANE

ChemComp-NXL:
(2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide / antibiotic, inhibitor*YM

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • enterococcus faecium (bacteria)
KeywordsHYDROLASE / L / D-TRANSPEPTIDATION / PEPTIDOGLYCAN / ANTIBIOTIC RESISTANCE / AVIBACTAM / NXL104 / ANTIBIOTIC

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