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TitleStructural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge.
Journal, issue, pagesBiochemistry, Vol. 57, Page 2065-2068, Year 2018
Publish dateJan 23, 2018 (structure data deposition date)
AuthorsLiu, L.K. / Dai, Y. / Abdelwahab, H. / Sobrado, P. / Tanner, J.J.
External linksBiochemistry / PubMed:29578336
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-6c7s:
Structure of Rifampicin Monooxygenase with Product Bound
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-FAD:
FLAVIN-ADENINE DINUCLEOTIDE / FAD*YM

ChemComp-RFH:
(1E,3S,4R,5S,6R,7R,8R,9S,10S,11E,13E)-15-amino-1-{[(2S)-5,7-dihydroxy-2,4-dimethyl-8-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-1,6,9-trioxo-1,2,6,9-tetrahydronaphtho[2,1-b]furan-2-yl]oxy}-7,9-dihydroxy-3-methoxy-4,6,8,10,14-pentamethyl-15-oxopentadeca-1,11,13-trien-5-yl acetate

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • nocardia farcinica (strain ifm 10152) (bacteria)
KeywordsOXIDOREDUCTASE / Rifampicin

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