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TitleDual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity.
Journal, issue, pagesCell Chem Biol, Vol. 25, Page 571-, Year 2018
Publish dateNov 16, 2017 (structure data deposition date)
AuthorsChennamadhavuni, D. / Saavedra-Avila, N.A. / Carreno, L.J. / Guberman-Pfeffer, M.J. / Arora, P. / Yongqing, T. / Koay, H.F. / Godfrey, D.I. / Keshipeddy, S. / Richardson, S.K. ...Chennamadhavuni, D. / Saavedra-Avila, N.A. / Carreno, L.J. / Guberman-Pfeffer, M.J. / Arora, P. / Yongqing, T. / Koay, H.F. / Godfrey, D.I. / Keshipeddy, S. / Richardson, S.K. / Sundararaj, S. / Lo, J.H. / Wen, X. / Gascon, J.A. / Yuan, W. / Rossjohn, J. / Le Nours, J. / Porcelli, S.A. / Howell, A.R.
External linksCell Chem Biol / PubMed:29576533
MethodsX-ray diffraction
Resolution2.6 - 3.2 Å
Structure data

PDB-6bnk:
Crystal structure of TCR-MHC-like molecule
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-6bnl:
Crystal structure of TCR-MHC-like molecule
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-AGH:
N-{(1S,2R,3S)-1-[(ALPHA-D-GALACTOPYRANOSYLOXY)METHYL]-2,3-DIHYDROXYHEPTADECYL}HEXACOSANAMIDE

ChemComp-HOH:
WATER

ChemComp-QWV:
N-[(2S,3R)-3-hydroxy-1-{[6-O-(3-phenylpropanoyl)-alpha-D-galactopyranosyl]oxy}octadecan-2-yl]hexacosanamide

Source
  • mus musculus (house mouse)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Lipids Cancer

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