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TitleComplex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.
Journal, issue, pagesCancer Cell, Vol. 33, Page 664-675.e4, Year 2018
Publish dateDec 18, 2017 (structure data deposition date)
AuthorsYu, X. / Chan, H.T.C. / Orr, C.M. / Dadas, O. / Booth, S.G. / Dahal, L.N. / Penfold, C.A. / O'Brien, L. / Mockridge, C.I. / French, R.R. ...Yu, X. / Chan, H.T.C. / Orr, C.M. / Dadas, O. / Booth, S.G. / Dahal, L.N. / Penfold, C.A. / O'Brien, L. / Mockridge, C.I. / French, R.R. / Duriez, P. / Douglas, L.R. / Pearson, A.R. / Cragg, M.S. / Tews, I. / Glennie, M.J. / White, A.L.
External linksCancer Cell / PubMed:29576376
MethodsX-ray diffraction
Resolution2.99 Å
Structure data

PDB-6fax:
Complex of Human CD40 Ectodomain with Lob 7.4 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.99 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / CD40 / engineered Fab / agonist / mAb

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