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Structure paper

TitleStructural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor.
Journal, issue, pagesJ. Mol. Biol., Vol. 430, Page 1324-1335, Year 2018
Publish dateSep 15, 2017 (structure data deposition date)
AuthorsHuang, J. / Dey, R. / Wang, Y. / Jakoncic, J. / Kurinov, I. / Huang, X.Y.
External linksJ. Mol. Biol. / PubMed:29573988
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-6b0t:
Structural Insights into the Induced-fit Inhibition of Fascin by a Small Molecule
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-C7V:
4-methyl-N-(1-{[4-(trifluoromethyl)phenyl]methyl}-1H-indazol-3-yl)-1,2-oxazole-5-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Metastaic cancers / Small-molecule inhibitors / actin-bundling / Domain rotation

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