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Structure paper

TitleActivity and fidelity of human DNA polymerase alpha depend on primer structure.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 6824-6843, Year 2018
Publish dateAug 23, 2017 (structure data deposition date)
AuthorsBaranovskiy, A.G. / Duong, V.N. / Babayeva, N.D. / Zhang, Y. / Pavlov, Y.I. / Anderson, K.S. / Tahirov, T.H.
External linksJ. Biol. Chem. / PubMed:29555682
MethodsX-ray diffraction
Resolution2.95 Å
Structure data

PDB-6as7:
CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN DNA-PRIMED DNA TEMPLATE AND DCTP
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-DCP:
2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-CO:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • unidentified (others)
Keywordsreplication/dna / B-FAMILY DNA POLYMERASE / DNA REPLICATION / REPLICATION / replication-dna complex

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