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Structure paper

TitleT cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.
Journal, issue, pagesNat. Immunol., Vol. 19, Page 397-406, Year 2018
Publish dateDec 28, 2017 (structure data deposition date)
AuthorsWun, K.S. / Reijneveld, J.F. / Cheng, T.Y. / Ladell, K. / Uldrich, A.P. / Le Nours, J. / Miners, K.L. / McLaren, J.E. / Grant, E.J. / Haigh, O.L. ...Wun, K.S. / Reijneveld, J.F. / Cheng, T.Y. / Ladell, K. / Uldrich, A.P. / Le Nours, J. / Miners, K.L. / McLaren, J.E. / Grant, E.J. / Haigh, O.L. / Watkins, T.S. / Suliman, S. / Iwany, S. / Jimenez, J. / Calderon, R. / Tamara, K.L. / Leon, S.R. / Murray, M.B. / Mayfield, J.A. / Altman, J.D. / Purcell, A.W. / Miles, J.J. / Godfrey, D.I. / Gras, S. / Price, D.A. / Van Rhijn, I. / Moody, D.B. / Rossjohn, J.
External linksNat. Immunol. / PubMed:29531339
MethodsX-ray diffraction
Resolution2.95 - 3.21 Å
Structure data

PDB-6c09:
Ternary crystal structure of the 3C8 TCR-CD1c-monoacylglycerol complex
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-6c15:
CD1c in complex with phosphatidylcholine
Method: X-RAY DIFFRACTION / Resolution: 3.21 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EKG:
(2R)-2,3-dihydroxypropyl hexadecanoate

ChemComp-D10:
DECANE

ChemComp-K:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

ChemComp-D12:
DODECANE

ChemComp-6PL:
(4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE / phospholipid*YM

ChemComp-NA:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-BME:
BETA-MERCAPTOETHANOL

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / T cell Receptor / Antigen Presentation

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