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Title | Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. U.S.A., Vol. 115, Page 3249-3254, Year 2018 |
Publish date | Sep 13, 2017 (structure data deposition date) |
![]() | Nelp, M.T. / Kates, P.A. / Hunt, J.T. / Newitt, J.A. / Balog, A. / Maley, D. / Zhu, X. / Abell, L. / Allentoff, A. / Borzilleri, R. ...Nelp, M.T. / Kates, P.A. / Hunt, J.T. / Newitt, J.A. / Balog, A. / Maley, D. / Zhu, X. / Abell, L. / Allentoff, A. / Borzilleri, R. / Lewis, H.A. / Lin, Z. / Seitz, S.P. / Yan, C. / Groves, J.T. |
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Methods | X-ray diffraction |
Resolution | 2.755 - 2.822 Å |
Structure data | ![]() PDB-6azu: ![]() PDB-6azv: ![]() PDB-6azw: |
Chemicals | ![]() ChemComp-HEM: ![]() ChemComp-SO4: ![]() ChemComp-C4V: ![]() ChemComp-HOH: ![]() ChemComp-C51: |
Source |
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![]() | OXIDOREDUCTASE / holoenzyme IDO1 / oxidoreductase/oxidoreductase inhibitor / IDO1 heme-displaced ligand-bound / oxidoreductase-oxidoreductase inhibitor complex / IDO1/FXB-001116 crystal structure |