タイトル | Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach. |
---|
ジャーナル・号・ページ | ACS Chem. Biol., Vol. 13, Page 915-921, Year 2018 |
---|
掲載日 | 2017年12月16日 (構造データの登録日) |
---|
著者 | Amato, A. / Lucas, X. / Bortoluzzi, A. / Wright, D. / Ciulli, A. |
---|
リンク | ACS Chem. Biol. / PubMed:29529862 |
---|
手法 | X線回折 |
---|
解像度 | 1.9 - 2.7 Å |
---|
構造データ | PDB-6fap: Crystal structure of human BAZ2A PHD zinc finger in complex with Fr23 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-6fhq: Crystal structure of human BAZ2B PHD zinc finger in complex with Fr 21 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-6fhu: Crystal structure of BAZ2A PHD zinc finger in complex with H3 3-mer peptide 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å PDB-6fi0: Crystal structure of BAZ2A PHD zinc finger in complex with Fr 19 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6fi1: Crystal structure of human BAZ2B PHD zinc finger in complex with Fr23 手法: X-RAY DIFFRACTION / 解像度: 2.7 Å PDB-6fkp: Crystal structure of BAZ2A PHD zinc finger in complex with H3 10-mer AA mutant peptide 手法: X-RAY DIFFRACTION / 解像度: 2.0 Å |
---|
化合物 | ChemComp-D3H: ~{N}-(4-aminophenyl)-2-azanyl-ethanamide
ChemComp-DE5: 2-azanyl-~{N}-(1,3-thiazol-2-yl)ethanamide
ChemComp-DEW: 2-azanyl-1-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-yl)ethanone
|
---|
由来 | ![](img/tx_human.gif) homo sapiens (ヒト)
|
---|
キーワード | TRANSCRIPTION (転写 (生物学)) / PHD / zinc finger (ジンクフィンガー) / BAZ2B / BAZ2A / bromodomain (ブロモドメイン) / fragment / competition (コンペティション) / epigenetic (エピジェネティクス) / PHD zinc finger / histone (ヒストン) / 3-mer / epigenetic H3 / Fr 19 / Fr19 / ligandability / H3 |
---|